Primary chronic adrenal insufficiency of autoimmune etiology. Review of the literature on a case
DOI:
https://doi.org/10.53591/rug.v125i2.382Keywords:
Addison's disease, Chronic adrenal insufficiency, Primary autoimmune adrenal insufficiencyAbstract
The incidence of adrenal insufficiency is 1: 100 000. The primary causes are rarer, barely constitute 40% and are frequently linked to infectious diseases or autoimmune etiology. The objective is to describe the presentation of a case of primary chronic adrenal insufficiency of autoimmune etiology diagnosed in the General Hospital of Cienfuegos. Patient of 25 years, comes for abdominal pain. During the examination he reported a change in skin color and episodes of hypoglycemia. It is hypotensive. The complementary ones gave light hyponatremia. Subsequent study showed elevated ACTH and low Cortisol. Rest of the blood and imaging tests without alteration. The patient is under medication and followed up by consultation. Without complications.
References
Arlt Wiebke. Disorders of the Adrenal Cortex. En: Longo DL, Kasper DL, Jameson JL, Fauci AS, Hauser SL, Loscalzo J, editors. Harrison´s principles of internal medicine 19th ed. New York: McGraw-Hill; 2015.
Nieman Lynnette K. Corteza Suprarrenal. En: Goldman Lee, Schafer Andrew I, editors. Goldman-Cecil Medicine 25th ed. Philadelphia. Elsevier Saunders; 2016
Spiegel Allen M. Principios de Endocrinologia. En: Goldman Lee, Schafer Andrew I, editors. Goldman-Cecil Medicine 25th ed. Philadelphia. Elsevier Saunders; 2016.
Jameson Larry J. Approach to the patient with Endocrine Disorders En: Longo DL, Kasper DL, Jameson JL, Fauci AS, Hauser SL, Loscalzo J, editors. Harrison´s principles of internal medicine 19th ed. New York: McGraw-Hill; 2015.
AW. Michels, GS. Eisenbarth. Inmunologic Endocrine Disorders. J Allergy Clin Immunol. 2010 February ; 125(2): 226–S237.
E. Cirillo, M. Salerno, C. Pignata. Genetic Basis of Altered Central Tolerance and Autoimmune Diseases: A Lesson from AIRE Mutations. International Reviews of Immunology. 2012; 31:344–362.
Betterle C, Dal Pra C, Mantero F, et al. Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction. Endocr Rev 2002; 23:327–364.
GJ. Kahaly. Polyglandular Autoinmune Syndrome Type II. Presse Medicale. 2012; 41: 663-670.
Jabbour SA. Cutaneous manifestations of endocrine disorders: a guide for dermatologists. Am J Clin Dermatol. 2003;4(5):315-31.
MS. Anderson. Update in Endocrine Autoinmunity. J Clin Endocrinol Metab. 2008; 93:3663-3670.
Letelier Maria Carolina B. Sindromes Endocrinos Autoinmunes: Cuando Sospechar y Estudiar un Sindrome Poliglandular. Med Clin. 2013; 24(5): 784-789.
M.Alimohammadi et Al. Autoimmune Polyendocrine Syndrome Type 1 and NALP5, a Parathyroid Autoantigen. N Engl J Med. 2008; 358: 101108.
Arraya Veronica Q. Trastornos de la Glandula Renal: Diagnóstico y Tratamiento. Med Clin. 2013; 24(5): 768-777.
Colao A, Petersenn S, Newell-Price J, et al. A 12-Month Phase 3 Study of Pasireotide in Cushing’s Disease. N Engl J Med 2012; 366:.914-924.
Feelders R, Hofland L. Medical Treatment of Cushing’s Disease. J Clin Endocrinol Metab 2013; 98: 425–438.
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