Total thyroidectomy vs radical thyroidectomy with functional lymphadenectomy in thyroid cancer
Evaluation of recurrence 3 years after the surgical procedure
Keywords:
total thyroidectomy, radical thyroidectomyAbstract
This study is based on evaluating the effectiveness of these procedures, total thyroidectomy vs radical thyroidectomy with functional lymphadenectomy in thyroid cancer, their relationship with the recurrence of patients after three years of performing them.
Retrospective study of patients admitted to the National Oncology Institute Dr. Juan Tanca Marengo (SOLCA Hospital in the city of Guayaquil) from January 2006 to December 2008 with a diagnosis of thyroid cancer, who have completed follow-up at 6.12 ,24 or 36 months. It is vital for scientific research to compare two treatments, in this case surgical procedures to draw relevant conclusions to improve patient management and avoid the number of complications.
Patient data were collected from the clinical history, including age, sex, ultrasound report, pathological diagnosis (follicular, papillary, undifferentiated, medullary carcinoma), laboratory data (thyroid hormones, thyroglobulin), stage according to TNM classification, surgical procedure used (total or radical thyroidectomy with functional lymphadenectomy), use of radioactive iodine, postoperative complications (recurrent laryngeal nerve injury, hypoparathyroidism), follow-up (months) and presence or absence of recurrence in each of these. After collecting the patients, after selection by inclusion and exclusion criteria, they were separated into two groups for analysis: Group A underwent total thyroidectomy, and Group B underwent radical thyroidectomy with functional lymphadenectomy.
References
Velasco S, Solar A, Cruz F, Quintana J, León A, Mosso L, et al. Tiroglobulina y sus limitaciones en el seguimiento del carcinoma diferenciado del tiroides.Rev Méd Chile.2007;135:506- 511
Ito Y, Miyauchi A. Thyroidectomy and Lymph Node Dissection in Papillary Thyroid Carcinoma. Journal of Thyroid Research. 2011;2011:1- 6
Jameson J, Weetman A. Enfermedades de la glándula tiroides. En: Longo D, Fauci A, Kasper D, Hauser S, Jameson J, Loscalzo J. Principios de Medicina Interna de Harrison. 18ava edición. Estados Unidos de América: McGraw Hill; 2012
Kebebew E, Duh Q, Clark O. Total Thyroidectomy or Thyroid Lobectomy in Patients with Low-risk Differentiated Thyroid Cancer: Surgical Decision Analysis of a Controversy Using a Mathematical Model. World J. Surg.2000;24:1295–1302
Shrestha SK, Joshi MR, Sharma SK. Total thyroidectomy: the treatment of choice in differentiated thyroid carcinoma. Kathmandu University Medical Journal.2005;3(1):35-38
Efremidou E, Papageorgiou M, Liratzopoulos N, Manolas K. The efficacy and safety of total thyroidectomy in the management of benign thyroid disease: a review of 932 cases. Can J Surg.2009;52(1):39-44
Kim W, Yoon J, Kim W, Kim T, Kim E, Kim J, et al. Change of Serum Antithyroglobulin Antibody Levels Is Useful for Prediction of Clinical Recurrence in Thyroglobulin-Negative Patients with Differentiated Thyroid Carcinoma. J Clin Endocrinol Metab.2008;93(12):4683–4689
Fitzgerald PA. Endocrine Disorders. En: Papadakis MA, McPhee SJ, Rabow MW, Berger TG, eds. CURRENT Medical Diagnosis & Treatment 2014. New York: McGraw-Hill; 2013
Weetman AP, Jameson JL. Chapter 341. Disorders of the Thyroid Gland. In: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J, eds. Harrison's Principles of Internal Medicine. 18th ed. New York: McGraw Hill; 2012.
Lee GA, Masharani U. Chapter 42. Disorders of the Thyroid Gland. In: Lalwani AK, ed. CURRENT Diagnosis & Treatment in Otolaryngology— Head & Neck Surgery. 3rd ed. New York: McGraw-Hill; 2012
Habra MA, Busaidy NL, Yeung SJ, Vassilopoulou-Sellin R. Chapter 45. Endocrine and Metabolic Complications of Cancer Therapy. In: Kantarjian HM, Wolff RA, Koller CA, eds. The MD Anderson Manual of Medical Oncology. 2nd ed. New York: McGraw-Hill; 2011.
Clark OH. Chapter 16. Thyroid & Parathyroid. In: Doherty GM, ed. CURRENT Diagnosis & Treatment: Surgery. 13th ed. New York: McGraw Hill; 2010.
Lal G, Clark OH. Chapter 26. Endocrine Surgery. In: Gardner DG, Shoback D, eds. Greenspan’s Basic & Clinical Endocrinology. 9th ed. New York: McGraw-Hill; 2011
Lal G, Clark OH. Chapter 38. Thyroid, Parathyroid, and Adrenal. In: Brunicardi FC, Andersen DK, Billiar TR, Dunn DL, Hunter JG, Matthews JB, Pollock RE, eds. Schwartz's Principles of Surgery. 9th ed. New York: McGraw-Hill; 2010.
Inabnet WB, Gagner M. Endoscopic thyroidectomy: supraclavicular approach and Takami HE, Ikeda Y. Endoscopic thyroidectomy via an axillary or anterior chest approach. In: Gagner M, Inabnet WB, eds. Minimally Invasive Endocrine Surgery. Lippincott, Williams and Wilkins; 2002
Roseman BJ, Clark OH. Neck mass. In: Souba W, et al, eds. ACS Surgery— Principles and Practice. 6th ed. WebMD Corporation; 2007
González M., Andrade P., Contreras O., Irarrazabal V., Paladines P., Inturias R., Umaña M. Sobrevida en cáncer de tiroides: seguimiento de 365 pacientes por un periodo de 37 años. Rev. Chilena de Cirugía.2002;54(4):329-335
Roh J., Park C. Sentinel lymph node biopsy as guidance for central neck dissection in patients with papillary thyroid carcinoma. Cancer.2008;113:1527-1531
Saatian M., Badie B., Shahriari S., Fattahi F., Rasoolinejad M. FNA diagnostic value in patients with neck masses in two teaching hospitals in Iran. Acta Medica Iranica.2011;49(2):85-88
Durante C., Montesano T., Attard M., Torlontano M., Monzani F., Constante G., y col. Long-term surveillance of papillary thyroid cancer patients who do not undergo postoperative radioiodine remnant ablation: is there a role for serum thyroglobulin measurement?. J Clin Endocrinol Metab.2012;97(8):2748-2753
Costa S., Giugliano G., Santoro L., De Carvalho A., Massaro M., Gibelli B. Role of prophylactic central neck dissection in cN0 papillary thyroid cancer. Acta otorhinolaryngologica italic.2009;19:61-69
Bardet S., Malville E., Rame J., Babin E., Samama G, De Raucourt D, y col. Macroscopic lymph-node involvement and neck dissection predict lymph node recurrence in papillary thyroid carcinoma. European Journal of Endocrinology.2008;158:551-560
Brassard M., Borget I., Edet-Sanson A., Giraudet A., Mundler O., Toubeau M., y col. Long-term follow-up of patients with papillary and follicular thyroid cancer: A prospective study on 715 patients. J Clin Endocrinol Metab.2011;96(5):1352-1359
Schlumberger M., Baudin E. Serum thyroglobulin determination in the follow-up of patients with differentiated thyroid carcinoma. European Journal of Endocrinology.2008;138:249-252
Huang O., Wu W., Wang O., You J., Li Q., Huang D, y col. Sentinel lymph node biopsy is unsuitable for routine practice in younger female patients with unilateral low-risk papillary thyroid carcinoma.BMC Cancer.2011;11:386- 92
Roh J., Park J., Park C. Prevention of postoperative hypocalcemia with routine oral calcium and vitamin D supplements in patients with differentiated papillary thyroid carcinoma undergoing total thyroidectomy plus central neck dissection. Cancer.2009;115:251-258
