Biotechnological Applications of Graphene Derivatives: Bibliometric Evaluation and Emerging Trends
DOI:
https://doi.org/10.53591/easi.V3i2.2980Keywords:
biosensor engineering, electrochemical sensor design, nanomaterials engineering, biomedical engineering applicationsAbstract
A bibliometric analysis was conducted to evaluate the use of graphene and its derivatives in biotechnology, with a focus on biosensors and tissue engineering. A total of 3,151 Scopus-indexed documents (2010–2024) were analyzed using Bibliometrix and VOSviewer to assess scientific production, citations, international collaboration, and thematic evolution. Results showed an annual growth rate of 30.98%, with China, South Korea, and Iran leading research output. In biosensors, graphene derivatives (GO and rGO) have been integrated with nanometals, polymers, and 3D architectures to develop sensitive devices for clinical diagnostics, environmental monitoring, and food safety. In tissue engineering, their combination with biomaterials such as chitosan, collagen, and hydroxyapatite has enhanced mechanical and bioactive properties, supporting bone, cardiac, and neural regeneration. Emerging trends include multifunctional hybrid materials, portable technologies, non-invasive diagnostics, and 3D bioprinting. Despite progress, challenges remain in synthesis standardization, clinical validation, and large-scale production.
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